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506 However, clinical trials for C9ORF72-targeted therapies WVE-004 and Tadnersen (IONIS-BIIB5Rx) have been terminated due to poor efficacy

10.3390/antiox14091033 38 GuerraC.MorrisD.SipinA.KungS.FranklinM.GrayD.et al (2011)

The 1993 New England Journal of Medicine study on tretinoin showed an 80% increase in Type I collagen formation in photodamaged skin after 10 to 12 months of treatment