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Colitis model research has examined GHK-Cus macrophage polarization activity in the context of intestinal inflammation, where the M1 to M2 shift documented in wound healing models may reduce mucosal inflammatory burden during recovery phases

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The study observed that GHK-Cu exposure possibly suppresses the activation of NF-B by modifying the phosphorylation of its inhibitor IB, thereby reducing the expression of inflammatory mediators

Therefore, the enhanced intestinal morphology observed in the present study likely contributed to improved nutrient absorption and physiological performance of the developing embryos and post-hatch ducklings 93,103