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Discontinuation of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before conception or during early pregnancy was associated with greater gestational weight gain and increased risks of preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy in a cohort comprised primarily of women with , according to findings published today in 1 Balancing Benefits, Risks of GLP-1 RAs Optimizing hyperglycemia and weight before pregnancy is strongly recommended, as diabetes and obesity elevate the risk of pregnancy complications and long-term metabolic disease in offspring

Mol Pharmacol 1999

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