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These results suggest a link between GSH oxidation and Ero1 activity that, if not direct, could be through the reduction of nonnative disulphides or members of the PDI family

10.1016/S1474-4422(09)70017-1 106

Martinez-Outschoorn, U

Skin Aging and Collagen Loss Skin aging involves several structural changes: reduced collagen synthesis increased collagen degradation decreased elastin integrity slower cellular turnover These processes contribute to wrinkles, skin laxity, and reduced resilience