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All DPP-4 inhibitors can be given in a standard dose without the need for dose titrations (10)

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113,114,115,116 The lactate shuttle refers to the transport of lactate between cells, tissues, and organs as a product of glycolysis and a substrate for respiration, which summarizes the process of lactate transmembrane migration and serves as a bridge between anaerobic glycolysis and aerobic respiration

A comprehensive 2024 meta-analysis published in Frontiers in Pharmacology evaluated 50 randomized controlled trials involving over 4,150 participants