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Ice crystal formation disrupts the peptides structure, and repeated freeze-thaw cycles have been observed to reduce biological activity by 20-50% (2)
Beginning too many changes at once makes it difficult to attribute effects to specific components
Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease
B.JakobP.KlingenbergR.ObeidS.HegD.et al (2018)
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