COVID induces lymphocyte dysfunction, cytokine shifts, endothelial activation, and systemic inflammatory stress
[PMC free article: PMC2702831] [PubMed: 19240062] 248
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The pathway analysis by KEGG on differentially expressed proteins suggested that the significantly affected pathways were steroid hormone biosynthesis, propanoate metabolism, systemic lupus erythematosus, non-alcoholic fatty liver disease (NAFLD), fatty acid degradation, fatty acid metabolism, citrate cycle (TCA cycle), carbon metabolism, fat digestion and absorption, Parkinsons disease (PD), oxidative phosphorylation, ubiquinone and other terpenoid-quinone biosynthesis, alcoholism (Fig
158,443 Apart from primary liver cancer, PD-1 resistant NSCLC cells were characterized by a markedly lower glycolytic reserve and exhibited a significantly higher reliance on OXPHOS compared to PD-1 sensitive NSCLC cells, which implies that tumor progression leads to complex changes in lactate metabolism flux
