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The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia

The gluteal region has thicker subcutaneous tissue and fewer nerve endings than the abdomen, so some patients report less discomfort there

However, with the discovery of new metal-dependent cell death including ferroptosis and cuproptosis, increasing evidence shows that there is a complex relationship between mitochondrial quality control and metal-dependent cell death

doi: 10.1007/s40265-015-0529-0

When the generic product differs in formulation from the RLD, additional in vivo pharmacokinetic and clinical efficacy studies are required