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Guo P et al (2022) Alzheimers disease with sleep insufficiency: a cross-sectional study on correlations among clinical characteristics, orexin, its receptors, and the blood-brain barrier

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Individual variation in response is significant and poorly characterized

Weight loss of at least 5% was achieved in 90% of participants, weight loss of at least 10% was achieved in 69% and weight loss of at least 15% was achieved in 48%