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Elevated stress levels may trigger cravings for high-calorie, low-nutrient foods, while insulin resistance affects how your body processes glucose, leading to fat storage instead of fat burning

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A dedicated phase 2a substudy in people with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) used MRI to measure liver fat and found that, after 24 weeks, retatrutide reduced relative liver-fat content by about 81% at the 8 mg dose and about 82% at 12 mg, versus essentially no change on placebo