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While we applaud the efforts to rapidly disseminate advice in the fast-evolving circumstances of a novel virus pandemic, the challenge for physicians is that the guidance in some aspects lacks consistency (Fig

In summary, combination treatment with metformin and liraglutide, a GLP-1 analogue, has a synergistic effect against PA-induced endothelial dysfunction

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Studies suggest it can block the NF-B pathway and reduce inflammatory cytokines like TNF- and IL-6 without causing skin darkening, making it a potentially safe option for systemic use