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While ferroptosis-targeted clinical research in gastric cancer remains absent, systematic investigations of Erastin, RSL3, and the FSP1 pathway have yielded promising results in various solid tumors, establishing a preclinical research framework that integrates mechanisms, pharmacological agents, and combination strategies

FBXL3, beyond targeting CRY proteins, also indirectly influences REV-ERB-mediated repression of BMAL1 and CRY1 , as elevated REV-ERB levels in FBXL3 -mutant mice enhance transcriptional repression (Shi et al., 2013

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