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Accordingly, the downregulation of MMP-1, MMP-3 and MMP-13 expressions and the upregulation of TIMP-1 expression were reported due to the use of TQ in chondrocytes and cartilage in the animal model

The guideline also stresses careful patient selection, monitoring, and consideration of access, cost, and long-term use, Jenkinson said, potentially adding to logistical complications of widespread adoption

Position the patient comfortably with the selected injection site exposed (Fig 2)