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For these effects, the drug was first approved by the FDA for the management of T2D in adults in 2010, then, in 2014, for the treatment of obesity in adults who have at least one weight-related condition, and later on, in 2019, also for the treatment of children 10 years or older with T2D

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When the integrity of the BBB is breached, infiltrating blood components and immune cells activate perivascular glia, igniting an inflammatory cascade that accelerates neuronal damage