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However, after four and twenty-eight days of treatment, phenobarbital increased the concentrations of P450 in all four strains

Deficient O-glycosylation compromises mucin production and disrupts the mucus barrier, thereby facilitating inflammasome activation (e.g., caspase-1, IL-1, IL-18) and exacerbating inflammation

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Dysregulation of KEAP1-NRF2 activity has been extensively demonstrated in cellular and animal models of ALS and in postmortem ALS motor cortex and spinal cord samples, so dysregulation of the NRF2/ARE antioxidant and cytoprotective pathway could be a possible mechanism underlying the progressive neurodegeneration in ALS and severity of the disease

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