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They are constantly in contact with sunlight (UV rays), food, saliva, cosmetics, and products like tobacco, all of which can affect the delicate lip tissue over time and cause pigmentation changes 4,5

Some additional health conditions that can contribute to weight gain and cause difficulty losing weight include: Polycystic ovary syndrome (PCOS) Heart failure Kidney or liver problems Metabolic conditions like high blood pressure and cholesterol Thyroid disease (especially hypothyroidism) If you have other health conditions, talk to your healthcare provider about whether they could be affecting your weight loss on semaglutide

Acknowledgements This work was supported by the National Natural Science Foundation of China (21102182), the Natural Science Foundation of Jiangsu Province (BK2012760, China), Fundamental Research Funds for the Central Universities (2632018ZD09, China), and Excellent Science and Technology Innovation Team of Jiangsu Province Universities in 2015 (China)

This compression can cause pain, tingling, numbness, and weakness in the hand and fingers

He shares that, similar to going off a medication, tapering gives our bodies the time to readjust to stopping treatment