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For those who have it, the SURPASS 2 trial (1,879 participants with type 2 diabetes, 40 weeks) provides the diabetes specific comparison: Tirzepatide 15 mg reduced HbA1c by 2.30 percentage points Semaglutide 1 mg reduced HbA1c by 1.86 percentage points All three doses of tirzepatide were statistically superior to semaglutide for A1c reduction Real world data from over 10,000 patients confirmed the same pattern: people starting tirzepatide achieved lower HbA1c and greater weight loss than those starting semaglutide after 12 months of treatment

Completely stopping does result in different effects

FDA states that if you also use insulin or a sulfonylurea , talk proactively about dose adjustments to reduce the risk of hypoglycemia

Step 5: Solution should be clear

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