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19851991, 2014 [53] V
In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols
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For this drug with an elimination half-life of 24 hours, if the dose is doubled to reach a plasma concentration of 20 g/ml, then it will take 21 days instead of 20 days to reach an acceptable threshold of 0.01 g/ml
J Anal Spectrom
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