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Biochim Biophys Acta 1728(3):199205

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Additional warnings include risk of gallbladder disease (report right upper quadrant pain or jaundice), acute kidney injury from dehydration, and worsening of severe gastrointestinal disease including gastroparesis

It has been a very effective medication for lowering blood sugar for many years, with the added benefit of weight loss .[1] In response to the weight loss seen in patients with type II diabetes, Novo Nordisk sent semaglutide into FDA trials for approval as a weight loss medication

[68] found patients with nonalcoholic fatty liver disease (NAFLD) have elevated APOA5 expression compared to healthy controls