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ART exerts its antitumor effects through multiple pathways, including PPAR-SCD and PI3K/AKT/FKHR signaling (Xu et al., 2022

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[10] At 8 hours following the start of the NAD+ infusion, it was shown that the NAD+ group had significant declines in the liver function enzymes gamma glutamyl transferase, lactate dehydrogenase, and aspartate aminotransferase as well as a large increase in plasma bilirubin

That FDA approval means it has undergone rigorous clinical testing with robust data on visceral fat reduction, and the mechanistic basis for its effects applies equally to menopausal visceral fat accumulation

There aren't a ton of medications that circumvent some sort of hormonal effects, which is a big gripe that patients and providers alike have because these medications have a lot of side effects