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In SURMOUNT-1, all doses of tirzepatide showed significant improvements in mental health scores compared to placebo

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However, ERT has lower therapeutic efficacy when started in advanced stages of Fabry disease 11,12

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DOI: 10.1136/bmjmed-2025-002150,

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Its impact on monoamine neurotransmitters offers unique insights into hunger, satiety, and potentially even food reward pathways

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There are many reasons an association can exist, but if the medication is not causing the adverse effect, then those associations are not a directly related safety concern

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