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Scand J Urol Nephrol 1999

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Specifically, mice in the HFD+sema group were intraperitoneally injected with 30 mol/kg semaglutide (Novo Nordisk, Copenhagen, Denmark) once daily for another 12 weeks

Its sequence AcNlecyclo[AspHisDPheArgTrpLys]NH incorporates a norleucine substitution, a Dphenylalanine substitution, and a lactam bridge that cyclises the molecule, conferring markedly greater stability and resistance to enzymatic degradation than the native linear hormone

In one comparative study, n-propyl gallate provided the most robust protection across multiple readouts of neuroprotection, outperforming gallic acid and other analogues (40)