Here, we use a large mammalian animal model with cardiac electrophysiological properties close to that of humans 45 to test the hypothesis that (i) the chronotropic effect of GLP-1 is independent of the autonomic nervous system, (ii) the chronotropic effect of GLP-1 is a direct effect on the heart through the GLP-1 receptor, (iii) GLP-1 affects electrophysiological properties of the sinus node, (iv) the chronotropic effect is mediated by changes of the phosphorylation state of key proteins that control Ca 2+ homeostasis in myocytes, and (v) the signalling effect is elicited in pacemaker myocytes in the sinus node
Subsections: 9.11 Free Radicals & Oxidative Stress 9.12 What is an Antioxidant
In order to increase insulin sensitivity and satiety and aid in weight loss, this medicine addresses metabolic processes
Zhu T, Chen Z, Jiang G, Huang X
two-way ANOVA with Sidaks multiple comparisons test ( g, h, i )