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diagnosis is based primarily on clinical history and physical examination

This approach remains off-label and needs careful riskbenefit assessment

Although less likely, such a scenario is not unusual, and has been visualized in the prototypical 2 adrenergic receptor: both ligand-free and antagonist-bound 2 adrenergic receptors can form a complex with nucleotide-free Gs 22,23

Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian Journal of Basic Medical Sciences, US National Library of Medicine, National Institutes of Health

When these side effects occur, they usually resolve on their own within a few days