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Deeper needles (1.5mm+) are used for collagen induction but can damage hair follicles if used on scalp

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They exhibit anti-inflammatory and chondroprotective effects by suppressing nuclear factor kappa B (NF-B), protein kinase A (PKA)/cAMP Response Element-Binding protein (CREB), and MAPK pathways, reducing cytokine synthesis, oxidative stress, and endoplasmic reticulum stress

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The medication should be discontinued at least 2 months before a planned pregnancy, and effective contraception should be used during treatment

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