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26% of patients achieved more than 30% weight loss compared to 0% on lifestyle changes alone

This further inhibits the excessive activation of inflammatory pathways such as the NLRP3 inflammasome and cGASSTING pathway, while maintaining the homeostasis of ATP synthesis in cells, alleviating cell apoptosis and tissue damage, and playing a key protective role in the early compensatory stage of diseases such as heart failure and atherosclerosis

However, researchers note that the weight loss itself, not direct drug toxicity, is the most likely mechanism

The HPLC conditions were as follows: the column was a Phenomenex HYDRO-RP column (C18, polar endcapped

Plasma was diluted x100 with assay buffer before analysis