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The predicted weight reduction for each cohort was then used to predict the effect sizes for the primary endpoints in the OSA and OA baskets independently, acknowledging that this approach could underestimate weight lossindependent or drug mechanismdependent effects, which may additionally contribute to efficacy

Since the synaptic connections formed on the mushroom spine can usually last for a long time, it is also considered to be a mature memory spine, where the long-term memory is stored (Parnass et al., 2000

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This allows the drugs to help the body regulate blood sugar levels