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Epigenetic modulation of gene expression by dietary isothiocyanates Despite the fact that most work on the cellular effects of ITC relates to their influence on detoxifying enzymes, recent data support the effect of these dietary compounds on the reactivation of epigenetically silenced genes in cancer cells, particularly through the inhibition of HDAC activity ( Reference Dashwood and Ho 52 )
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Circulation 89 , 355360 (1994)
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