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A 2023 study out of the University of British Columbia found that GLP-1 drugs were associated with an increased risk of stomach paralysis, pancreatitis and bowel obstruction

Weight Loss Results at 48 Weeks: Key Percentage Findings At 48 weeks, the 12 mg retatrutide dose produced a mean body weight reduction of approximately 24.2%, compared with approximately 2.1% in the placebo group, with weight loss still ongoing at trial end

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was funded by the PRIME JP17gm5910013 and the LEAP JP17gm0010004 from the Japan Agency for Medical Research and Development, and JSPS KAKENHI 17K08264

Some plans have formulary exclusions for weight loss drugs and drugs prescribed off-label