These findings, although obtained from models of oxidative stress and mitochondrial dysfunction rather than in autism models, are highly relevant because they target biological mechanism that are also characteristic of ASD (Sachdeva et al., 2022)
Apart from the use of oral contraceptives and/or various anti-androgenic drugs in PCOS, there is extensive literature evidence of positive effects when using specific drugs to counteract IR, such as metformin (4, 5), or when administering complementary substances, such as inositols, alpha lipoic acid, or combinations of these (6-11)
[DOI] [PubMed] [Google Scholar] 34.Wang X., Ilarraza R., Tancowny B.P., Alam S.B., Kulka M
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Notably, under hypoxic or electron transportlimited conditions, SDH can reverse its activity to reduce fumarate to succinate using electrons from the CoQ 10 pool, a metabolic rerouting, allowing cells to maintain redox balance when oxygen is scarce 77
