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In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO 2 and sO 2 and increases in pCO 2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression

(1999) found that mice lacking cldn5 (claudin-5) exhibited a leaky BBB for particles of sizes that ordinarily are under tight regulation

Lammel T, Boisseaux P, Fernndez-Cruz M-L, Navas JM

Supports immune function by aiding detoxification

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