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Besides the issue of its effectiveness, insight into the role of acetyl-l-carnitine in the pathophysiology of ALS was provided by Grossini et al

Inhibition of the cAMP-degrading enzyme phosphodiesterase 4 (PDE4) enhances and sustains these cAMP responses, and disruption of G s or cAMP signalling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation