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These receptors are extensively expressed on immune cells, including macrophages and DCs, as well as in specific tissues [202,203,204,205]

However, McCombe and Henderson [23] noted that It is possible that individual variability in immune responsiveness means that individual patients have different immune responses in ALS. A clear understanding of the dynamic changes that occur within the immune system over the course of disease [104] is essential for developing an effective treatment for ALS