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Reactive oxygen species can attack biomembranes, enzymes, proteins, and nucleic acids (Venditti et al., 2013)

8-week washout: Required after cycles lasting 1216 weeks, and preferred by experienced researchers for full receptor restoration

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Instead, the researchers were also unsure why the gap closed after an additional four weeks of study, but offered the explanations that the different groups may not have been eating enough to get the full benefit of their training, or, conversely, had overtrained

Hepatic function had to be stable, defined as no clinically significant change in disease status, as judged by the investigator