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Beyond established pharmacological mechanisms such as improved glucose-dependent insulin secretion, delayed gastric emptying, and appetite modulation, growing evidence indicates that the intestinal microbial ecosystem may contribute to interindividual differences in treatment outcomes
Premedication was administered using 3 mg/kg of xylazine, followed by general anesthesia with 50 mg/kg of ketamine
Obesity-mediated immune modulation: one step forward, (Th)2 steps back
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Importantly, 100 mg/kg cinchonine was found to ameliorate hepatic steatosis and hepatic fibrosis in NASH mice
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