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Researchers designed IGF-1 LR3 to enhance these biological effects while improving stability in circulation

This stability, combined with its broad tissue applicability, has made it one of the most extensively studied regenerative peptides in preclinical science

Antioxid Redox Signal 7:662672 Zeevalk GD, Bernard LP, Sinha C, Ehrhart J, Nicklas WJ (1998) Excitotoxicity and oxidative stress during inhibition of energy metabolism

Oxidative stress has been proved to be the major pathogenic mechanism of amiodarones tissue damage effects

Gene expressions of IL-6 (A and E) , IGF-1 (B and F) and IGF-2 (C and G) were compared between IL-6-treated cells and control group and between IL-6 plus inhibitor co-treated cells and IL-6 group