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Severe or persistent diarrhea defined as more than six loose stools daily lasting beyond 48 hoursrequires clinical assessment to prevent complications and rule out alternative causes unrelated to the weight loss medication

Clearly though, such sustained effect will be completely lost after a few weeks of treatment interruption, as recent clinical evidence suggests 34, 35

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A 2025 study reported evidence of telomere length stabilization or modest lengthening, raising the possibility that metabolic therapies may influence pathways related to genomic stability and replicative lifespan [16]