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For procurement, this creates a specific challenge: even when IV biosimilar pembrolizumab enters in 2028, the clinical population may have shifted to subcutaneous Keytruda Qlex, which remains branded

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J Biol Chem 267: 21432-21437, 1992

With insurance coverage, a savings card, or a manufacturer direct program, the actual cost can be $25 to $449 per month

The persistence of fatigue often correlates with the severity of gastrointestinal side effects, which tend to diminish as tolerance develops