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Further accumulation of uremic toxins, which leads to uremic syndrome, can, among others, cause neurotoxicity, disruption in the BBB integrity, oxidative stress, neuroinflammation, and disturbance of brain neurotransmitter amino acids balance (Hamed, 2019)

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A recent meta-analysis showed that L-carnitine has numerous cardioprotective properties, which may be mediated through improved mitochondrial function, elevated antioxidant status and lowered oxidative stress 8