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S.BrcicL.et al (2012)

How GLP-1 Medications May Support Brain Health Emerging research suggests several ways GLP-1 medications could benefit the brain: Improved Insulin Signaling GLP-1 receptor activation may enhance insulin sensitivity in brain tissue, potentially supporting memory pathways and cognitive processing

370 Notably, the NATALEE trial included 40% of patients who were excluded from the MonarchE study due to having stage II and stage III N0 disease, making it a more comprehensive clinical trial of CDK4/6 inhibitors in early breast cancer to date

Some doctors are starting to listen: In one Swiss study (2), almost half of all general practitioners agreed with prescribing B12 for unexplained fatigue

In conclusion, we believe it is premature to conclude that the GLP-1 class of drugs has been established as having a good safety profile and is appropriate for a relatively early choice of therapy for type 2 diabetes