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Yet, the long-term effects of these changes are unknown ( Therefore, more information is needed concerning long-term supplementation, particularly when high doses are used

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Moreover, it was indicated that the presence of betanin contributed to the reduction of LDL in humans that reflected lipid peroxidation (Tesoriere et al., 2004)

Low ROS levels activate cell survival signaling pathways, such as the unfolded protein response and Nrf2 pathways, whereas high ROS levels activate cell death signaling pathways, such as apoptosis and necroptosis pathways 43

In basal keratinocytes, integrin expression increases at 0.1-10 M concentrations alongside enhanced p63 positivity