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Similar results were found in a clinical study in patients with T2DM, where administration of liraglutide, but not metformin, increased the relative abundance of Akkermansia , which is often associated with the improvement of gastric mucosa and also becomes severely depleted in diabetic patients [115]

Its Phase 3 evidence belongs to CagriSema (with semaglutide), not to cagrilintide as monotherapy

Abbreviations ACR: American College of Rheumatology CNS: central nervous system GABA: gamma-aminobutyric acid Kv: voltage-gated potassium channels LFT: liver function test NMDA: N-methyl-D-aspartate Declarations Acknowledgement None

This makes peptide therapy not only effective but also safe when guided by a physician

Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) on melatonin secretion by the pineal gland of young and old rats