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As treatment extends beyond three years, clinicians must consider how gastrointestinal tolerability evolves over time

You may be making better choices and having slightly smaller portions, but on a microdose, you should not be eating significantly less

PMID: 41997974 Nat Commun Intraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression

However, more powerful weight loss does not automatically mean treatment is right for every patient

We collaborated with the Mayo team to include factors on this risk calculator, like family history, women-specific risk factors and coronary calcium score, which alerts the clinician and patient that actual risk may be higher than indicated