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It plays a vital role in: Mitochondrial energy production (ATP synthesis) DNA repair and gene expression Cell signaling and metabolism As we age, NAD levels naturally decline , leading to fatigue, reduced cellular function, slower metabolism, and neurodegeneration

doi: 10.1016/j.tcb.2020.02.009 30 WuZFLiuXYDengNHRen Z and JiangZ

Considering their low MW and non-covalent nature of inhibition of TGR, these compounds were deemed appropriate for fragment-based design