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However, they address different pathophysiological defects: pioglitazone targets insulin resistance at the tissue level, while GLP-1 agonists target pancreatic beta cell function and satiety

There is no published, peer-reviewed randomized or controlled human trial of systemic GHK-Cu establishing efficacy or safety for any indication

The daily dosing requirement may be less convenient for some patients, though others prefer the flexibility of adjusting doses more frequently

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However, a limitation is that the trial was not blinded, meaning participants knew which drug and the dose they were receiving