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When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes

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As illustrated in Figure S15, TLR2 pep-orid-liposome reached a maximum concentration in tumors as early as 12 h post-administration, which exhibited greater efficient than that of orid-liposome at 24 h

it is simply distributed across a slightly larger volume of solvent