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discuss this with your prescriber, as lower doses may still provide clinical benefit

Future clinical trials should evaluate the use of new and existing tests to assess biomarkers, such as IDO1/TDO2 expression and kynurenine levels, to guide treatment decisions

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Here, we review the role of GLP-1 and the actions of associated therapies on glucose metabolism, the gutrenal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM