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ArticlePubMed 95

Chronic stress can impact: Hormone balance Nervous system regulation Cellular energy production Nutrient utilization Over time, this leads to mental fatigue, physical exhaustion, and reduced resilience

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A BMI of 35 or higher qualifies on its own

Follow-up work might move to animal models where histological scoring, imaging, and functional tests allow for more complex observations, always with appropriate controls and ethical oversight