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However, limited published efficacy data and variable skin absorption remain significant challenges

What Studies Show About Muscle Loss on GLP-1 Drugs The evidence on lean mass loss during GLP-1 therapy comes from the same large clinical trials that established these drugs as effective for weight loss

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Monitoring your health while using a GLP-1 receptor agonist is important, and certain symptoms or situations, such as the ones below, should prompt a consultation with a doctor: New or worsening gastrointestinal symptoms, such as persistent nausea, vomiting, diarrhoea, or signs of dehydration 7 , 27