Discussion This observational cohort study describes real-world utilization patterns and characteristics of patients dispensed an SGLT2i or GLP-1 RA in the US using data from Optum CDM in the period following changes to the landscape for treatment and prevention of CKD in type 2 diabetes (later period, July 2021September 2023) as well as temporal changes in utilization and baseline characteristics relative to the period prior (earlier period, January 2012June 2021)
16 However, a portion of spending on these therapies is expected to persist for the non-weight loss indications (e.g., major adverse cardiovascular events [MACE], metabolic dysfunction associated steatohepatitis [MASH], and obstructive sleep apnea [OSA])
People who have severe gastrointestinal conditions like inflammatory bowel disease (IBD) or gastroparesis should not go on GLP-1s, and neither should people with a personal or family history of multiple endocrine neoplasia 2A, multiple endocrine neoplasia 2B, medullary thyroid cancer, or pancreatitis
Reductions in total cholesterol levels were also evident in the RG7697/NNC0090-2746 treatment group
Start your intake Why Surgeons Ask You to Pause GLP-1 Medications Before Surgery GLP-1 receptor agonists slow stomach emptying and reduce appetite by designthis mechanism is what makes semaglutide effective for weight loss and blood sugar control